PSC, high IgE, but normal IGG4

Hello PSC community,

I have a diagnosis of the early onset of PSC in the central ducts. My IgE levels are three times what they should be but IgG4 is normal. I’m wondering if anyone else has this and can offer any explanation.

Many thanks,


When you say central ducts are you referring to large duct PSC? Elevated liver enzymes are par for the course with this disease. Make sure you are under the care of a hepatologist associated with a hospital that does liver transplants. They will have access to the best people and technology to monitor the disease progression and be able to do interventions when needed throughout the process. We will be here for you all the way so know that we have your back.

Kind Regards,

Mark Wilson, Moderator
Primary Sclerosing Cholangitis (PSC) Support Group