Interesting…anybody here had any experience with Statins?

Extremely interesting study that supports my experience with statins. Brief view of my story: I had a campylobacter GI infection in 2019 and my LFTs spiked to 6x ULN. Oral meds wouldn’t fully relieve my symptoms and colonoscopy ultimately confirmed I had UC. I was eventually started on Entyvio infusions. GI symptoms resolved but my LFTs remained 2-3x ULN so my local GI was suspicious of PSC. MRI was negative and liver biopsy was negative. Enzymes stayed up… I got a second opinion from a hepatologist at Mount Sinai in NYC. His pathologist reviewed my biopsy slides and they diagnosed me with small duct PSC.
Despite never having a traditional symptom of PSC, I was started on ursodiol 1200 daily in hopes of slowing progression. Still, LFTs were elevated 1.5-2x ULN. Annual MRIs have thankfully demonstrated no progression.
Throughout this time, my cholesterol was in the 225-250 range despite having a relatively healthy diet, exercising, meditating, breathwork, etc. i was started on Crestor 10mg last year and for the first time in four years…all my LFTs normalized.
I tend to think it’s a combination of good gut health, healthy lifestyle, stress reduction and the right meds. At least it’s what has worked for me.

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Worth mentioning is that this isn’t really a study of the effects of statins on PSC, it’s simply a correlation of outcomes for IBD patients who’ve taken or not taken statins over a period of 4 years after IBD diagnosis. Correlation =/= causation. Also worth mentioning is that there’s serious side effects to consider (statins arn’t really intended to be used by people living healthy lifestyles).

Welcome back, Brian.
Glad you doing so well.