New study gives hope for treatment of PBC

General Articles and Research
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Here’s an article of interest regarding a new study giving hope of a treatment for PBC.

Mark

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That is a great news. Will it be FFA approved for use in PSC ?

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There was a phase 2 trial with PSC patients: A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis. I don’t see any follow up studies. Results from this trial found significant decrease in ALP with the high-dose OCA group vs. placebo; however, as dosage increased, so did pruritus.

Studies have found that PSC patients have significantly improved outcomes when their ALP is within a near-normal range (typically 1-1.5xULN). Relative improvements outside of this near-normal range do not appear to affect outcome. This OCA study unfortunately lacks an analysis of patient near normalization.

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Thank you!! Not a good news :frowning:

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I was asked to participate in a clinical trial involving OCA and chose not to.