Greetings PSCers! I started a thread on Fenofibrate over two years ago (you can reach it by searching on “Fenofibrate”. Time for an update on my experience with this drug. My ALP results continue to slowly decrease and it is now at 150 (it was 500 before I started Fenofibrate and I have been on it since March 2017). Everything else is the same: no apparent drug side effects and no PSC progression (just had MRI: continues to be “mild” impacts unchanged from previous MRIs). What I continue to not be able to say is that using Fenofibrate will change the outcome of this disease - that sort of evidence can only be generated through clinical trials, studies etc.