# PLN-74809 Info?

**URL:** <https://forum.livingwithpsc.org/t/pln-74809-info/4363>\
**Category:** Symptoms & Treatment\
**Created:** [December 1, 2020, 8:17pm UTC](https://forum.livingwithpsc.org/t/pln-74809-info/4363 "2020-12-01T20:17:04Z")\
**Posts on this page:** 6\
**Page:** 1

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**Author:** ![Trevor2123](https://avatars.discourse-cdn.com/v4/letter/t/f475e1/32.png) [@Trevor2123](https://forum.livingwithpsc.org/u/Trevor2123)\
**Post date:** [December 1, 2020, 8:17pm UTC](https://forum.livingwithpsc.org/t/pln-74809-info/4363/1 "2020-12-01T20:17:04Z")

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I was just contacted by my Hep about participating in a phase 2 clinical study of PLN-74809 . Has anyone heard about this study , it sounds like it was used for pulmonary fibrosis and now used for PSC . Phase one only had 48 studies internationally.

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**Author:** ![tomavera](https://avatars.discourse-cdn.com/v4/letter/t/94ad74/32.png) [@tomavera](https://forum.livingwithpsc.org/u/tomavera)\
**Post date:** [December 2, 2020, 8:12am UTC](https://forum.livingwithpsc.org/t/pln-74809-info/4363/2 "2020-12-02T08:12:52Z")

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Hi. I read about it and the results look very good. Find out more at [www.pliantrx.com](http://www.pliantrx.com).  
They write:  
Our main program, PLN-74809, focuses on the activation of TGF-β in bile ducts and liver cells in the PSC, potentially slowing or stopping disease progression. Studies in animal models and explanted liver fibrotic tissue from PSC patients show a strong antifibrotic effect of PLN-74809. We are currently registering a trial version of Phase 2a with PLN-74809 to PSC.

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**Author:** ![Trevor2123](https://avatars.discourse-cdn.com/v4/letter/t/f475e1/32.png) [@Trevor2123](https://forum.livingwithpsc.org/u/Trevor2123)\
**Post date:** [December 2, 2020, 4:01pm UTC](https://forum.livingwithpsc.org/t/pln-74809-info/4363/3 "2020-12-02T16:01:45Z")

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Thanks for the info

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**Author:** ![plgshoes](https://sea1.discourse-cdn.com/flex019/user_avatar/forum.livingwithpsc.org/plgshoes/32/1900_2.png) [@plgshoes](https://forum.livingwithpsc.org/u/plgshoes)\
**Post date:** [December 3, 2020, 2:08am UTC](https://forum.livingwithpsc.org/t/pln-74809-info/4363/4 "2020-12-03T02:08:42Z")

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I was in the phase 1 trial and gad no issues. It’s the 3rd study I’ve taken part in. My numbers went down during the study but I had a procedure a month before the study started so I’m not sure if it helped. And, they haven’t gone up since it finished.

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**Author:** ![Trevor2123](https://avatars.discourse-cdn.com/v4/letter/t/f475e1/32.png) [@Trevor2123](https://forum.livingwithpsc.org/u/Trevor2123)\
**Post date:** [December 3, 2020, 4:44am UTC](https://forum.livingwithpsc.org/t/pln-74809-info/4363/5 "2020-12-03T04:44:33Z")

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Any advise to someone taking part in a study ?

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**Author:** ![plgshoes](https://sea1.discourse-cdn.com/flex019/user_avatar/forum.livingwithpsc.org/plgshoes/32/1900_2.png) [@plgshoes](https://forum.livingwithpsc.org/u/plgshoes)\
**Post date:** [December 26, 2020, 7:27pm UTC](https://forum.livingwithpsc.org/t/pln-74809-info/4363/6 "2020-12-26T19:27:19Z")

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No advice. I had no adverse affects. They haven’t gotten back to me the results, but I was one of the first to take the drug trial so maybe it’s not finished.