# New study gives hope for treatment of PBC

**URL:** <https://forum.livingwithpsc.org/t/new-study-gives-hope-for-treatment-of-pbc/4823>\
**Category:** Articles and Research\
**Created:** [November 16, 2021, 2:42am UTC](https://forum.livingwithpsc.org/t/new-study-gives-hope-for-treatment-of-pbc/4823 "2021-11-16T02:42:05Z")\
**Posts on this page:** 5\
**Page:** 1

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**Author:** ![fcmmark](https://sea1.discourse-cdn.com/flex019/user_avatar/forum.livingwithpsc.org/fcmmark/32/2189_2.png) [@fcmmark](https://forum.livingwithpsc.org/u/fcmmark)\
**Post date:** [November 16, 2021, 2:42am UTC](https://forum.livingwithpsc.org/t/new-study-gives-hope-for-treatment-of-pbc/4823/1 "2021-11-16T02:42:05Z")

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Here’s an article of interest regarding a new study giving hope of a treatment for PBC.

> **[New study gives hope for treatment of PBC, the silent liver disease](https://www.foxnews.com/health/pbc-silent-liver-disease-possible-treatment)**
>
> Primary Biliary Cholangitis (PBC) is an autoimmune disease where the small bile ducts of the liver become inflamed. The disease often goes undetected, leading to cirrhosis of the liver, liver failure, and possibly death. But a recent report suggests...

Mark

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**Author:** ![Olivera](https://avatars.discourse-cdn.com/v4/letter/o/a88e4f/32.png) [@Olivera](https://forum.livingwithpsc.org/u/Olivera)\
**Post date:** [November 18, 2021, 7:31am UTC](https://forum.livingwithpsc.org/t/new-study-gives-hope-for-treatment-of-pbc/4823/2 "2021-11-18T07:31:30Z")

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That is a great news. Will it be FFA approved for use in PSC ?

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**Author:** ![jtb](https://sea1.discourse-cdn.com/flex019/user_avatar/forum.livingwithpsc.org/jtb/32/723_2.png) [@jtb](https://forum.livingwithpsc.org/u/jtb)\
**Post date:** [November 22, 2021, 3:55pm UTC](https://forum.livingwithpsc.org/t/new-study-gives-hope-for-treatment-of-pbc/4823/3 "2021-11-22T15:55:25Z")

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There was a phase 2 trial with PSC patients: [A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157171/). I don’t see any follow up studies. Results from this trial found significant decrease in ALP with the high-dose OCA group vs. placebo; however, as dosage increased, so did pruritus.

Studies have found that PSC patients have significantly improved outcomes when their ALP is within a near-normal range (typically 1-1.5xULN). Relative improvements outside of this near-normal range do not appear to affect outcome. This OCA study unfortunately lacks an analysis of patient near normalization.

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**Author:** ![Olivera](https://avatars.discourse-cdn.com/v4/letter/o/a88e4f/32.png) [@Olivera](https://forum.livingwithpsc.org/u/Olivera)\
**Post date:** [November 22, 2021, 4:10pm UTC](https://forum.livingwithpsc.org/t/new-study-gives-hope-for-treatment-of-pbc/4823/4 "2021-11-22T16:10:03Z")

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Thank you!! Not a good news ☹

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**Author:** ![JeffDC1](https://sea1.discourse-cdn.com/flex019/user_avatar/forum.livingwithpsc.org/jeffdc1/32/402_2.png) [@JeffDC1](https://forum.livingwithpsc.org/u/JeffDC1)\
**Post date:** [November 25, 2021, 3:35am UTC](https://forum.livingwithpsc.org/t/new-study-gives-hope-for-treatment-of-pbc/4823/5 "2021-11-25T03:35:25Z")

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I was asked to participate in a clinical trial involving OCA and chose not to.