# Articles and Research **URL:** https://forum.livingwithpsc.org/c/general/news-and-research/16.md [Latest](https://forum.livingwithpsc.org/latest.md) · [Categories](https://forum.livingwithpsc.org/categories.md) --- ## [About the Articles and Research category](https://forum.livingwithpsc.org/t/about-the-news-and-research-category/22)
**Author:** [@system](https://forum.livingwithpsc.org/u/system)\ **Replies:** 0\ **Last updated:** [June 6, 2016, 9:16am UTC](https://forum.livingwithpsc.org/t/about-the-news-and-research-category/22 "2016-06-06T09:16:59Z")
Articles may not be peer reviewed or authoritative. Please do not use them as a basis for self-treating --- ## [PSC Partners Conference | PSC Support and Education | PSC Partners Seeking a](https://forum.livingwithpsc.org/t/psc-partners-conference-psc-support-and-education-psc-partners-seeking-a/4987)
**Author:** [@Birdy](https://forum.livingwithpsc.org/u/Birdy)\ **Replies:** 0\ **Last updated:** [May 31, 2022, 3:43am UTC](https://forum.livingwithpsc.org/t/psc-partners-conference-psc-support-and-education-psc-partners-seeking-a/4987 "2022-05-31T03:43:42Z")
This weekend is the virtual conference. For those who weren’t aware. Please sign up! Hope to meet you there! --- ## [Vancomycin Trial](https://forum.livingwithpsc.org/t/vancomycin-trial/4714)
**Author:** [@MzzP](https://forum.livingwithpsc.org/u/MzzP)\ **Replies:** 12\ **Last updated:** [March 22, 2022, 2:43pm UTC](https://forum.livingwithpsc.org/t/vancomycin-trial/4714 "2022-03-22T14:43:27Z")
This is opening up again. I do believe when I attempted to get in a couple years ago your ALP had to be 1x5 above the normal: At the time I qualified, happy to say I don’t right now - however I take an antibiotic daily… --- ## [Hypothesis on Vancomycin 'brand' differences for PSC effectiveness](https://forum.livingwithpsc.org/t/hypothesis-on-vancomycin-brand-differences-for-psc-effectiveness/4748)
**Author:** [@rjm](https://forum.livingwithpsc.org/u/rjm)\ **Replies:** 55\ **Last updated:** [January 31, 2022, 9:07am UTC](https://forum.livingwithpsc.org/t/hypothesis-on-vancomycin-brand-differences-for-psc-effectiveness/4748 "2022-01-31T09:07:18Z")
I’ve read a lot about PSC’ers on Vanco finding certain brands work and certains ones don’t. The ‘theory’ is that somehow they are subtly different at the molecular level and certain ‘brands’ by luck work on PSC (by - t… --- ## [New study gives hope for treatment of PBC](https://forum.livingwithpsc.org/t/new-study-gives-hope-for-treatment-of-pbc/4823)
**Author:** [@fcmmark](https://forum.livingwithpsc.org/u/fcmmark)\ **Replies:** 4\ **Last updated:** [November 25, 2021, 3:35am UTC](https://forum.livingwithpsc.org/t/new-study-gives-hope-for-treatment-of-pbc/4823 "2021-11-25T03:35:25Z")
Here’s an article of interest regarding a new study giving hope of a treatment for PBC. Mark --- ## [Melatonin Regulation of Biliary Functions](https://forum.livingwithpsc.org/t/melatonin-regulation-of-biliary-functions/544)
**Author:** [@fcmmark](https://forum.livingwithpsc.org/u/fcmmark)\ **Replies:** 10\ **Last updated:** [July 20, 2021, 6:51pm UTC](https://forum.livingwithpsc.org/t/melatonin-regulation-of-biliary-functions/544 "2021-07-20T18:51:58Z")
My primary care doctor sent me this article which I have passed on to my hepatologist for his opinion. This is rather deep reading but it may be informative to the group. The full article can be found at this link. ht… --- ## [Bile ducts bioengineering](https://forum.livingwithpsc.org/t/bile-ducts-bioengineering/4534)
**Author:** [@Leo](https://forum.livingwithpsc.org/u/Leo)\ **Replies:** 14\ **Last updated:** [May 31, 2021, 10:38am UTC](https://forum.livingwithpsc.org/t/bile-ducts-bioengineering/4534 "2021-05-31T10:38:16Z")
Hi, Anybody heard about bioengineered bile ducts ? I have found an article https://www.nature.com/articles/547171a from 2017 describing potential methods and test procedures on animals showing promising results and was… --- ## [Oral vancomycin, ursodeoxycholic acid or no therapy for pediatric primary sclerosing cholangitis: a matched analysis](https://forum.livingwithpsc.org/t/oral-vancomycin-ursodeoxycholic-acid-or-no-therapy-for-pediatric-primary-sclerosing-cholangitis-a-matched-analysis/4473)
**Author:** [@CodyL](https://forum.livingwithpsc.org/u/CodyL)\ **Replies:** 5\ **Last updated:** [February 28, 2021, 12:35am UTC](https://forum.livingwithpsc.org/t/oral-vancomycin-ursodeoxycholic-acid-or-no-therapy-for-pediatric-primary-sclerosing-cholangitis-a-matched-analysis/4473 "2021-02-28T00:35:19Z")
This retrospective study of PSC patients found no therapeutic benefit from Vancomycin or UDCA compared to no treatment. https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31560 I think this is probably the larges… --- ## [Do you, or have you had, pulmonary disease associated with PSC?](https://forum.livingwithpsc.org/t/do-you-or-have-you-had-pulmonary-disease-associated-with-psc/4461)
**Author:** [@SusanG](https://forum.livingwithpsc.org/u/SusanG)\ **Replies:** 3\ **Last updated:** [February 23, 2021, 4:01am UTC](https://forum.livingwithpsc.org/t/do-you-or-have-you-had-pulmonary-disease-associated-with-psc/4461 "2021-02-23T04:01:29Z")
How many of us have issues with our lungs? If so, what do you experience, what tests have you had, and/or what have you been diagnosed with? I’ve been coughing, hoarse and with congested lungs for about eight months no… --- ## [PSC markers from 23AndMe / Promethease / SNPedia](https://forum.livingwithpsc.org/t/psc-markers-from-23andme-promethease-snpedia/4329)
**Author:** [@MBLand](https://forum.livingwithpsc.org/u/MBLand)\ **Replies:** 1\ **Last updated:** [November 13, 2020, 2:44am UTC](https://forum.livingwithpsc.org/t/psc-markers-from-23andme-promethease-snpedia/4329 "2020-11-13T02:44:33Z")
Hi all, I had gotten 23AndMe done back in 2013. At the time, I didn’t see anything related to PSC, but I downloaded my data and ran it through Promethease a few weeks ago, which for a $10 fee, pulls in info from various… --- ## [PSC with IBD Nutrition Study](https://forum.livingwithpsc.org/t/psc-with-ibd-nutrition-study/4256)
**Author:** [@MzzP](https://forum.livingwithpsc.org/u/MzzP)\ **Replies:** 17\ **Last updated:** [October 26, 2020, 8:08pm UTC](https://forum.livingwithpsc.org/t/psc-with-ibd-nutrition-study/4256 "2020-10-26T20:08:37Z")
I am going to paste the email I received from pscpartners.org - as it best explains the importance and urgency. I just received this email, so timing is of the essence if interested. Go to the Show More below video and … --- ## [British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis](https://forum.livingwithpsc.org/t/british-society-of-gastroenterology-and-uk-psc-guidelines-for-the-diagnosis-and-management-of-primary-sclerosing-cholangitis/3298)
**Author:** [@sr13](https://forum.livingwithpsc.org/u/sr13)\ **Replies:** 0\ **Last updated:** [August 12, 2019, 2:47pm UTC](https://forum.livingwithpsc.org/t/british-society-of-gastroenterology-and-uk-psc-guidelines-for-the-diagnosis-and-management-of-primary-sclerosing-cholangitis/3298 "2019-08-12T14:47:48Z")
\[https://gut.bmj.com/content/68/8/1356.full\] --- ## [Takes about 15 minutes! Thank You!](https://forum.livingwithpsc.org/t/takes-about-15-minutes-thank-you/3273)
**Author:** [@MzzP](https://forum.livingwithpsc.org/u/MzzP)\ **Replies:** 0\ **Last updated:** [July 29, 2019, 5:58pm UTC](https://forum.livingwithpsc.org/t/takes-about-15-minutes-thank-you/3273 "2019-07-29T17:58:00Z")
I belong to an Awesome FB Support Group for PSC, called PSC Partners Seeking a Cure\_ and this survey was posted. Have permission to post here and hoping to keep the data coming. Also highly recommend connecting with th… --- ## [Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies](https://forum.livingwithpsc.org/t/fasting-reduces-liver-fibrosis-in-a-mouse-model-for-chronic-cholangiopathies/2792)
**Author:** [@Julian1969](https://forum.livingwithpsc.org/u/Julian1969)\ **Replies:** 12\ **Last updated:** [January 26, 2019, 8:28pm UTC](https://forum.livingwithpsc.org/t/fasting-reduces-liver-fibrosis-in-a-mouse-model-for-chronic-cholangiopathies/2792 "2019-01-26T20:28:19Z")
Hi Everyone, Always researching…been researching ‘fasting’ recently and its ability to reset the immune system. Anyway found this study which I thought was interesting… --- ## [Vedolizumab article on transplant patients](https://forum.livingwithpsc.org/t/vedolizumab-article-on-transplant-patients/2682)
**Author:** [@JeffDC1](https://forum.livingwithpsc.org/u/JeffDC1)\ **Replies:** 0\ **Last updated:** [September 17, 2018, 2:03pm UTC](https://forum.livingwithpsc.org/t/vedolizumab-article-on-transplant-patients/2682 "2018-09-17T14:03:12Z")
Frida asked us to post this article. Looks interesting.-Jeff P2174 - Infectious Complications in Liver Transplant Patients Exposed to Vedolizumab for the Treatment of Inflammatory Bowel Disease Tuesday, Oct 17 10:30 AM… --- ## [New clinical trial starting (CVC, phase 2)](https://forum.livingwithpsc.org/t/new-clinical-trial-starting-cvc-phase-2/792)
**Author:** [@Ted](https://forum.livingwithpsc.org/u/Ted)\ **Replies:** 12\ **Last updated:** [September 17, 2018, 8:10am UTC](https://forum.livingwithpsc.org/t/new-clinical-trial-starting-cvc-phase-2/792 "2018-09-17T08:10:16Z")
Great to see lots of research activity in PSC area. I have seen couple of new clinical trial being announced recently. This one was today: http://www.newson6.com/story/30907229/tobira-therapeutics-announces-initiation-o… --- ## [1.5 mill Euro to research PSC and gut bacteria](https://forum.livingwithpsc.org/t/1-5-mill-euro-to-research-psc-and-gut-bacteria/2579)
**Author:** [@Annie](https://forum.livingwithpsc.org/u/Annie)\ **Replies:** 3\ **Last updated:** [August 4, 2018, 3:32pm UTC](https://forum.livingwithpsc.org/t/1-5-mill-euro-to-research-psc-and-gut-bacteria/2579 "2018-08-04T15:32:00Z")
I couldn’t find this in English but maybe you could use Google Translate. It says that the Norwegian research Center for PSC is going to research the meaning of gut bacteria for autoimmune diseases, especially Psc. Th… --- ## [Interesting abstract about faecal calprotectin and PSC-IBD](https://forum.livingwithpsc.org/t/interesting-abstract-about-faecal-calprotectin-and-psc-ibd/2558)
**Author:** [@Andreas](https://forum.livingwithpsc.org/u/Andreas)\ **Replies:** 3\ **Last updated:** [July 28, 2018, 6:26pm UTC](https://forum.livingwithpsc.org/t/interesting-abstract-about-faecal-calprotectin-and-psc-ibd/2558 "2018-07-28T18:26:18Z")
Hello! I found THIS interesting abstract. It suggests that the cause of elevated faecal calprotectin might be damage to the bile ducts, rather than colon inflammation, for PSC-patients with IBD in remission. This doesn’… --- ## [Journal papers OV treatment PSC UC and PSC (children and adults)](https://forum.livingwithpsc.org/t/journal-papers-ov-treatment-psc-uc-and-psc-children-and-adults/2030)
**Author:** [@DB1](https://forum.livingwithpsc.org/u/DB1)\ **Replies:** 2\ **Last updated:** [February 8, 2018, 7:06pm UTC](https://forum.livingwithpsc.org/t/journal-papers-ov-treatment-psc-uc-and-psc-children-and-adults/2030 "2018-02-08T19:06:41Z")
OV case study 35 adults randomized double blind trial PSC 2013.pdf (213.4 KB) OV case study on 14 children PSC UC 2014.pdf (1.7 MB) OV case study 15yrs old child and review current therapies PSC UC 2017.pdf (146.0 KB) --- ## [Obeticholic acid](https://forum.livingwithpsc.org/t/obeticholic-acid/1648)
**Author:** [@mr.crowley](https://forum.livingwithpsc.org/u/mr.crowley)\ **Replies:** 5\ **Last updated:** [December 25, 2017, 6:44am UTC](https://forum.livingwithpsc.org/t/obeticholic-acid/1648 "2017-12-25T06:44:55Z")
Hi to everyone, i don’t know if this is new but wanted to share: https://www.healio.com/hepatology/autoimmune-cholestatic-biliary-diseases/news/online/{7d872c73-9da3-4f47-819f-b88b220696b7}/intercept-announces-ocaliva-ef… --- ## [New therapeutic avenues](https://forum.livingwithpsc.org/t/new-therapeutic-avenues/1729)
**Author:** [@code](https://forum.livingwithpsc.org/u/code)\ **Replies:** 2\ **Last updated:** [December 13, 2017, 10:07am UTC](https://forum.livingwithpsc.org/t/new-therapeutic-avenues/1729 "2017-12-13T10:07:04Z")
A good article: http://gut.bmj.com/content/62/11/1642.full there is a headline in the article about smoking. is there anyone here starting smoking? :slight\_smile: --- ## [Orphan drug status granted in the United States for a drug that could treat psc](https://forum.livingwithpsc.org/t/orphan-drug-status-granted-in-the-united-states-for-a-drug-that-could-treat-psc/1504)
**Author:** [@kempj18](https://forum.livingwithpsc.org/u/kempj18)\ **Replies:** 1\ **Last updated:** [June 30, 2017, 12:33am UTC](https://forum.livingwithpsc.org/t/orphan-drug-status-granted-in-the-united-states-for-a-drug-that-could-treat-psc/1504 "2017-06-30T00:33:50Z")
IDN-7314 Granted orphan drug status in the United States. https://www.zacks.com/stock/news/265633/conatuss-psc-candidate-gets-orphan-designation-in-the-us Conatus's PSC Candidate Gets Orphan Designation in the US Zacks… --- ## [Early detection of biliary neoplasia/CCA](https://forum.livingwithpsc.org/t/early-detection-of-biliary-neoplasia-cca/1377)
**Author:** [@Ted](https://forum.livingwithpsc.org/u/Ted)\ **Replies:** 1\ **Last updated:** [April 22, 2017, 12:36am UTC](https://forum.livingwithpsc.org/t/early-detection-of-biliary-neoplasia-cca/1377 "2017-04-22T00:36:45Z")
Interesting new doctoral dissertation. Anybody doing regular ERC and brush cytology (BC)? EARLY DETECTION OF BILIARY NEOPLASIA IN PRIMARY SCLEROSING CHOLANGITIS Primary sclerosing cholangitis (PSC) is particularly c… --- ## [New PSC trial starting (Boston)](https://forum.livingwithpsc.org/t/new-psc-trial-starting-boston/610)
**Author:** [@Ted](https://forum.livingwithpsc.org/u/Ted)\ **Replies:** 8\ **Last updated:** [February 27, 2017, 6:55am UTC](https://forum.livingwithpsc.org/t/new-psc-trial-starting-boston/610 "2017-02-27T06:55:10Z")
Interesting clinical trial (phases 1 and 2) starting and soon accepting participants in Boston, MA area. This is about fecal microbiota transplantation. I have heard it was found to be life saving miracle in some relat… --- ## [NGM 282 Study Recruiting PSC Patients in Multiple States](https://forum.livingwithpsc.org/t/ngm-282-study-recruiting-psc-patients-in-multiple-states/1163)
**Author:** [@Textbook](https://forum.livingwithpsc.org/u/Textbook)\ **Replies:** 2\ **Last updated:** [December 15, 2016, 7:25pm UTC](https://forum.livingwithpsc.org/t/ngm-282-study-recruiting-psc-patients-in-multiple-states/1163 "2016-12-15T19:25:01Z")
http://www.ngm282pscstudy.com/ I am considering volunteering because I live in Michigan. --- ## [Medical marijuana as an anti inflammatory drug for UC and Crohns...closer to knowing 2 bacteria and fungi found in the gi tract of Crohns sufferers](https://forum.livingwithpsc.org/t/medical-marijuana-as-an-anti-inflammatory-drug-for-uc-and-crohns-closer-to-knowing-2-bacteria-and-fungi-found-in-the-gi-tract-of-crohns-sufferers/1061)
**Author:** [@Jam](https://forum.livingwithpsc.org/u/Jam)\ **Replies:** 1\ **Last updated:** [December 5, 2016, 5:23am UTC](https://forum.livingwithpsc.org/t/medical-marijuana-as-an-anti-inflammatory-drug-for-uc-and-crohns-closer-to-knowing-2-bacteria-and-fungi-found-in-the-gi-tract-of-crohns-sufferers/1061 "2016-12-05T05:23:54Z")
Wonder if there's and implications for psc --- ## [PSC (and Oral Vanco) slideset by dr Shah](https://forum.livingwithpsc.org/t/psc-and-oral-vanco-slideset-by-dr-shah/1066)
**Author:** [@Ted](https://forum.livingwithpsc.org/u/Ted)\ **Replies:** 0\ **Last updated:** [October 11, 2016, 4:28pm UTC](https://forum.livingwithpsc.org/t/psc-and-oral-vanco-slideset-by-dr-shah/1066 "2016-10-11T16:28:32Z")
Here is nicel PSC presentation with lots of Oral Vancomycin info from dr Shah. She was previously in charge (together with dr Cox) of the (still on-going) phase 3 Oral Vancomycin clinical trial at Stanford University. No… --- ## [Liver Congress 2016 updates (Norudca news)](https://forum.livingwithpsc.org/t/liver-congress-2016-updates-norudca-news/816)
**Author:** [@Ted](https://forum.livingwithpsc.org/u/Ted)\ **Replies:** 3\ **Last updated:** [April 27, 2016, 3:59am UTC](https://forum.livingwithpsc.org/t/liver-congress-2016-updates-norudca-news/816 "2016-04-27T03:59:35Z")
Any further news from the International Liver Congress in Barcelona this week? I think several PSC related trials are discussed. I found this showing NorUdca results. It will have phase 3 clinical trial next, so this… --- ## [JQ1 - Scientists Discover Molecule That Halts Accumulation of Scar Tissue in the Liver](https://forum.livingwithpsc.org/t/jq1-scientists-discover-molecule-that-halts-accumulation-of-scar-tissue-in-the-liver/785)
**Author:** [@Textbook](https://forum.livingwithpsc.org/u/Textbook)\ **Replies:** 0\ **Last updated:** [December 9, 2015, 8:57am UTC](https://forum.livingwithpsc.org/t/jq1-scientists-discover-molecule-that-halts-accumulation-of-scar-tissue-in-the-liver/785 "2015-12-09T08:57:21Z")
http://medicalxpress.com/news/2015-12-liver-fibrosis-wound.html --- ## [Anyone taking obeticholic acid? If so, concerns/results/stories to share?](https://forum.livingwithpsc.org/t/anyone-taking-obeticholic-acid-if-so-concerns-results-stories-to-share/674)
**Author:** [@LillyAnne](https://forum.livingwithpsc.org/u/LillyAnne)\ **Replies:** 11\ **Last updated:** [December 7, 2015, 4:52pm UTC](https://forum.livingwithpsc.org/t/anyone-taking-obeticholic-acid-if-so-concerns-results-stories-to-share/674 "2015-12-07T16:52:23Z")
Considering this medication as a clinical trial, curious to know if anyone else is currently on it and if there are any stories you would be willing to share. Thanks! [Next page](https://forum.livingwithpsc.org/c/general/news-and-research/16.md?page=1)